Rejuran is an injectable treatment containing polynucleotides, also known as PDRN. It is placed just under the skin and is used in skin-quality focused treatment plans after a medical consultation.

What areas can Rejuran be used for?

Rejuran is commonly discussed for areas where the skin appears thin, tired or crepey, including the under-eye area, cheeks and neck. Suitability depends on individual assessment.

Does Rejuran change facial shape or volume?

Rejuran is not intended to change facial shape or add facial volume. It is generally used as part of a skin-quality treatment plan.

Is there downtime after Rejuran treatment?

Temporary injection-site lumps, bruising, discomfort and swelling can occur. The Cosmenon page notes that small lumps may last up to three days. Individual recovery varies.

How many Rejuran treatments are usually recommended?

The Cosmenon page describes an initial series of three sessions, usually spaced four weeks apart, with maintenance treatment discussed depending on individual goals and clinical suitability.

Is a consultation required before Rejuran treatment?

Yes. A consultation is required to assess suitability, review risks and side effects, and determine whether treatment is appropriate.

Rejuran® Skin Treatment

Doctor-Led Skin Rejuvenation in Melbourne

Rejuran® is a medical skin treatment used in aesthetic practice to support overall skin quality. It involves the use of polynucleotides (PDRN)—biologically derived molecules that have been studied and utilised for their role in skin repair and regeneration.

At Cosmenon, this treatment is approached as part of a structured medical consultation, not a standalone cosmetic procedure.

A Different Approach to Skin Rejuvenation

Many treatments focus on volume or surface-level hydration. Rejuran® is often considered in patients where the goal is to support skin quality over time, rather than immediate structural change.

This may include concerns such as:

Skin texture and roughness
Early signs of ageing
Skin that appears tired or less resilient
Areas where skin is thinner (e.g. periocular region)

All treatment decisions are made after a full clinical assessment, including discussion of alternatives and whether treatment is appropriate.

How Rejuran® Works

Polynucleotides (PDRN) are being investigated for their interaction with:

Cellular repair pathways
Local inflammatory signalling
Fibroblast activity

In clinical practice, this is often discussed in the context of supporting skin quality over time, rather than producing immediate visible change.

At a cellular level, Rejuran acts primarily via signalling pathways that may promote fibroblast proliferation and up-regulates the synthesis of extracellular matrix components, including collagen and elastin. Rejuran may support cellular repair in metabolically stressed or damaged tissue.

This differs to energy devices such as lasers which cause a local trauma to the skin to achieve a response.

Over time, this may help improve skin texture, elasticity, and hydration. It may also improve the appearance of scars, pigmentation, texture and thinning skin.

It does not change facial shape or volume but instead focuses on improving the condition and quality of the skin itself.

Importantly:

Outcomes vary between individuals
Multiple sessions may be recommended
Results are not guaranteed

What to Expect

Rejuran® is typically performed as a series-based treatment, depending on individual assessment.

Patients should understand:

There may be visible injection points and swelling initially
Short-term downtime is common
Changes, if they occur, tend to develop gradually

For a detailed breakdown of timelines and what patients commonly notice, refer to:

→ Rejuran Results: How Long Until You Notice Them?

Doctor-Led Consultation

At Cosmenon, every patient undergoes:

Medical history review
Facial assessment (structure, skin quality, ageing pattern)
Discussion of suitability and alternatives
Clear explanation of risks, limitations, and expected variability

Treatment is only offered if it is considered clinically appropriate.

A More Informed Patient Experience

If you are considering treatments like Rejuran®, it is important to understand:

What the treatment is — and what it is not
How it compares to other injectable or device-based options
Why outcomes vary between patients
Listen to the Cosmenon - Aesthetics Explained podcast.
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Important Information

A consultation is required to determine suitability
All procedures carry risks and potential side effects
Individual outcomes vary

Book a Consultation

If you are considering a medically guided approach to skin quality and rejuvenation, a consultation is the appropriate first step.

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